Successful plasma exchange in type 1 leprosy reversal reaction.
نویسندگان
چکیده
A 24 year old man admitted to hospital with borderline lepromatous leprosy was treated with rifampicin, dapsone, and clofazimine. After four months he developed a reversal reaction and the diagnosis was modified to borderline tuberculoid leprosy. The dose of clofazimine was raised and prednisolone added to the regimen without any symptomatic response. His condition improved dramatically after five plasma exchanges on five successive days.
منابع مشابه
Diagnosis and treatment of leprosy type 1 (reversal) reaction.
Leprosy is a chronic granulomatous infection caused by the organism Mycobacterium leprae that primarily affects the skin and peripheral nerves. Leprosy has several distinct clinical presentations ranging from moderate to severe, with the extent of disease generally depending on the host's immune response to the infection. Treatment typically involves antimicrobials (eg, clofazimine, dapsone, ri...
متن کاملGranulomatous Reactivation during the Course of a Leprosy Infection: Reaction or Relapse
BACKGROUND Leprosy is a chronic granulomatous infectious disease and is still endemic in many parts of the world. It causes disabilities which are the consequence of nerve damage. This damage is in most cases the result of immunological reactions. OBJECTIVES To investigate the differences between a type 1 leprosy (reversal) reaction and relapse on using histopathology. METHODS The histopath...
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Type 1 reaction or reversal reaction is an acute inflammatory episode in the skin and peripheral nerves that is found in up to 30% of leprosy patients and commonly causes physical disabilities. Multidrug chemotherapy and viral infections are associated risk factors. In this study, 620 leprosy patients were evaluated. Reversal reactions were diagnosed in 121 cases (19.5%) and were most frequentl...
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An 11-year-old black Haitian boy presented with borderline lepromatous leprosy and was treated with rifampicin, dapsone, and clofazimine. After 4 months he developed a severe type 1 reversal reaction without nerve involvement. He was started on prednisolone (1 mg/kg daily). After 4 weeks of treatment with corticosteroids, his condition did not improve and the lesions remained painful. The patie...
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Leprosy is a chronic disease caused by Mycobacterium leprae. Its course is complicated by acute onset of inflammatory reactions which can occur before, during and after treatment of the disease. The reactions are classified as Type 1 reaction or reversal reaction and Type 2 reaction or erythema nodosum leprosum (ENL). Reversal reaction is a Type IV delayed type hypersensitivity reaction while e...
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ورودعنوان ژورنال:
- British medical journal
دوره 289 6459 شماره
صفحات -
تاریخ انتشار 1984